Drug-Linker Conjugates for ADC
Drug-Linker Conjugates for Antibody Drug Conjugates (ADCs) comprise of an active cytotoxic drug and an appropriate linker. After linked to a monoclonal antibody, those conjugates can be used for making ADCs, which are targeted agents for cancer cells with high selectivity and cytotoxicity.
The drug units in drug-linker conjugates are cytotoxic agents (i.e. ADC cytotoxins or payloads) with antitumor activity and can be classified in DNA damaging agents and tubulin inhibitors. The most commonly used DNA damaging agents in ADCs are Duocarmycins, Pyrrolobenzodiazepines, Camptothecins and Daunorubicins/Doxorubicins, while the popular tubulin inhibitors are Auristatins and Maytansinoids. Besides, there are also many traditional cytotoxic agents can be used in ADCs.
ADC linkers currently undergoing clinical evaluation are mostly classified into two categories: cleavable and noncleavable. Cleavable linkers rely on processes inside the cell to liberate the toxin, and noncleavable linkers require proteolytic degradation of the antibody portion of the ADC for release of the cytotoxic molecule.
Alle Drug-Linker Conjugates for ADC Isoform-spezifische Produkte anzeigen
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Drug-Linker Conjugates for ADC
(327)
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Auristatin
(45)
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Camptothecins
(33)
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Daunorubicins/
Doxorubicins (5)View all products
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Duocarmycins
(8)
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Maytansinoids
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Pyrrolobenzodiazepines
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Traditional Cytotoxic Agents
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Dual payloads
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Drug-Linker Conjugates for ADC Verwandte Produkte (500)
Verwandte Produkte (500)
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Drug-Linker Conjugates for ADC Isoform Comparison
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MC-GGFG-3-Methylenecyclobutyl-Exatecan
0 ImagesArt. -Nr.: HY-181184CAS. Nr.: 3109352-90-8MC-GGFG-3-Methylenecyclobutyl-Exatecan (Raludotatug-L-1-1) is a conjugate of the toxin molecule Exatecan (HY-13631) and the linker (HY-181185), and it can be used for the synthesis of ADC molecules.
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P5(PEG12)-VC-PAB-Exatecan
0 ImagesArt. -Nr.: HY-173625CAS. Nr.: 2928571-52-0P5(PEG12)-VC-PAB-Exatecan (LP3) is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor Exatecan (HY-13631) and a linker P5(PEG24)-VC-PAB to make antibody agent conjugate (ADC). P5(PEG12)-VC-PAB-Exatecan can be used for the research of tumor.
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LD-38
0 ImagesArt. -Nr.: HY-177495CAS. Nr.: 3094583-35-1LD-38 is a drug-linker conjugate for ADC. LD-38 consists of a topoisomerase 1 inhibitor (Exatecan) (HY-13631) and a highly hydrophilic stable and cleavable linker. LD-38 can be used for synthesis of ADCs, such as KA-3123-LD38.
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(R)-DM4-SPDP
0 ImagesArt. -Nr.: HY-126493ACAS. Nr.: 2245698-48-8(R)-DM4-SPDP is a conjugate made up of the linker SPDP and the toxic molecule DM4, and it can be used to prepare antibody-drug conjugates.
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Mal-PNU-159682
0 ImagesArt. -Nr.: HY-171508CAS. Nr.: 1204819-90-8Mal-PNU-159682 is a Drug-Linker Conjugates for ADC, composes of ADC linker (maleimide) and ADC cytotoxin PNU-159682 (HY-16700), and has anti-tumor activity.
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SPB (Standard)
0 ImagesArt. -Nr.: HY-104025RCAS. Nr.: 858128-57-1
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Deruxtecan-d4-1
0 ImagesArt. -Nr.: HY-13631ES2CAS. Nr.: 2760715-88-4Synonyms: MC-GGFG-DXD-d4-1Deruxtecan-d4-1 is the deuterium labeled Adenosine Deruxtecan (HY-13631E). Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.
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SG3199-Val-Ala-PAB (Standard)
0 ImagesArt. -Nr.: HY-101152RCAS. Nr.: 1595275-61-8SG3199-Val-Ala-PAB (Standard) is the analytical standard of SG3199-Val-Ala-PAB (HY-101152). This product is intended for research and analytical applications. SG3199-Val-Ala-PAB is an intermediate of Tesirine synthesis. Tesirine is a agent-linker conjugate for ADC which can be used for the research of several cancers.
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Mal-βAla-β-glucuronide-MMAE
0 ImagesMal-βAla-β-glucuronide-MMAE is a drug-linker conjugate. Mal-βAla-β-glucuronide-MMAE can be used for the synthesis of ADC.
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NHS-Modified MMAF TFA
0 ImagesArt. -Nr.: HY-139325ANHS-Modified MMAF (intermediat 210) TFA is an intermediate which can be used for producing the anti-mesothelin binder-agent conjugates (ADCs).
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Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal
0 ImagesArt. -Nr.: HY-400878CAS. Nr.: 2345732-83-2Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal, a glucocorticoid receptor agonist, is a drug-linker conjugate for ADC. Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal can be used to synthesize the anti-CD40 antibody agent conjugates (WO2019106608A1; example 9).
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sulfo-SPDB-DM4 (Standard)
0 ImagesArt. -Nr.: HY-101141RCAS. Nr.: 1626359-59-8sulfo-SPDB-DM4 (Standard) is the analytical standard of sulfo-SPDB-DM4 (HY-101141). This product is intended for research and analytical applications. sulfo-SPDB-DM4 is a agent-linker conjugate for ADC by using the maytansinebased payload (DM4, an antitubulin agent) via the sulfo-SPDB linker.
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AZ14170133-d5
0 ImagesArt. -Nr.: HY-145399SSynonyms: SG 3932-d5; AZ-0133-d5AZ14170133-d5 (SG 3932-d5) is the deuterium labeled AZ14170133 (HY-145399). AZ14170133 (SG 3932) is a Drug-Linker Conjugates for ADC, which comprises a topoisomerase inhibitor and a linker for ligand unit connecting. AZ14170133 can be used to synthesis antibody-drug conjugate (ADC).
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Deruxtecan-d6
0 ImagesArt. -Nr.: HY-13631ES1CAS. Nr.: 2760715-89-5Synonyms: MC-GGFG-DXD-d6Deruxtecan-d6 is the deuterium labeled Deruxtecan.
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Val-Ala-PABC-N(Mesylpropane)-Exatecan
0 ImagesArt. -Nr.: HY-164647CAS. Nr.: 2842021-73-0Val-Ala-PABC-N(Mesylpropane)-Exatecan is an agent-linker conjugate for ADC. Val-Ala-PABC-N(Mesylpropane)-Exatecan is a Exatecan (a DNA topoisomerase I inhibitor) d with cleavable Val-Ala-PABC-N(Mesylpropane) linker.
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BrAC-GGFG-Aminal-PI3K/mTOR-IN-21
0 ImagesArt. -Nr.: HY-185457BrAC-GGFG-Aminal-PI3K/mTOR-IN-21 is a conjugate of PI3K/mTOR-IN-21 (HY-185456) and Linker.
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DM1-MCC-PEG3-Biotin
0 ImagesArt. -Nr.: HY-W190944CAS. Nr.: 2183472-94-6DM1-MCC-PEG3-Biotin is a drug-linker conjugate for ADC.
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Mal-Val-Ala-amide-(3)PEA-PNU-159682
0 ImagesArt. -Nr.: HY-171507CAS. Nr.: 2682939-56-4Mal-Val-Ala-amide-(3)PEA-PNU-159682 is a Drug-Linker Conjugates for ADC, composes of ADC linker (Mal-Val-Ala-amide-(3)PEA) and ADC cytotoxin PNU-159682 (HY-16700), and has anti-tumor activity.
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Lys-SMCC-DM1 (Standard)
0 ImagesArt. -Nr.: HY-101982RCAS. Nr.: 1281816-04-3Synonyms: Lys-Nε-MCC-DM1 (Standard)Lys-SMCC-DM1 (Standard) is the analytical standard of Lys-SMCC-DM1 (HY-101982). This product is intended for research and analytical applications. Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is a agent-linker conjugates for ADC that can inhibit tubulin polymerization. Lys-SMCC-DM1 is the active metabolite of T-DM1. T-DM1 is a HER2-targeting ADC with a tubulin polymerization inhibitor DM1. Lys-SMCC-DM1 can be used in the research of breast cancer.
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SuO-Glu-Val-Cit-PAB-MMAE-d8-1
0 ImagesArt. -Nr.: HY-130989S1Synonyms: NHS-Glutarate-Val-Cit-PAB-MMAE-d8-1SuO-Glu-Val-Cit-PAB-MMAE-d8-1 (NHS-Glutarate-Val-Cit-PAB-MMAE-d8-1) is the deuterated-labeled SuO-Glu-Val-Cit-PAB-MMAE (HY-130989). SuO-Glu-Val-Cit-PAB-MMAE (NHS-Glutarate-Val-Cit-PAB-MMAE) consists a cleavable ADC linker (SuO-Glu-Val-Cit-PAB) and a potent tubulin inhibitor (MMAE). SuO-Glu-Val-Cit-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs).
